Why Can’t I Dm On Domain_10
| DM domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Drosophila melanogaster doublesex (dsx), nmr, 18 structures |
|||||||||
| Identifiers | |||||||||
| Symbol | DM | ||||||||
| Pfam | PF00751 | ||||||||
| InterPro | IPR001275 | ||||||||
| SMART | SM00718 | ||||||||
| SCOP2 | 1rvv / Telescopic / SUPFAM | ||||||||
|
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In molecular biology the
DM domain
is a protein domain first discovered in the doublesex proteins of
Drosophila melanogaster
and is also seen in
C. elegans
and mammalian proteins.[1]
In
D. melanogaster
the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sexual activity-specific polypeptides.[2]
These proteins are believed to office as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription.[3]
[4]
The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences .[2]
[5]
[half dozen]
The NMR analysis of the DSX DM domain
[half-dozen]
revealed a novel zinc module containing ‘intertwined’ CCHC and HCCC zinc-binding sites. The recognition of the DNA requires the carboxy-last basic tail which contacts the small-scale groove of the target sequence.
Proteins with this domain
[edit]
Proteins with the DM domain are found in many model organisms. Many
C. elegans
Mab
proteins comprise this domain, the best-known ane being mab-three.[1]
Human proteins containing this domain include DMRT1, DMRT2, DMRT3, DMRTA1, DMRTA2, DMRTB1, and DMRTC2; each of these take a mouse homolog.[7]
| Dmrt1-specific | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Dmrt1 | ||||||||
| Pfam | PF12374 | ||||||||
| InterPro | IPR022114 | ||||||||
|
|||||||||
DMRT1 homologs have an additional mutual domain C-terminal to the DM domain. This domain is only constitute in bony vertebrates, and neither its structure nor role is unknown.[8]
: species tree
Jpred predicts the man version of the department to be mostly coils; it also suggests a weak similarity to
PDB: 6BO4 by BLAST.[9]
| DMRTA motif | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DMA | ||||||||
| Pfam | PF03474 | ||||||||
| InterPro | IPR005173 | ||||||||
|
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DMRTA proteins have an boosted motif in their C-termina. This motif, ubiquitous in eukaryotes, has an unknown office. Information technology is similar in sequence to some ubiquitin-associated motifs.[10]
References
[edit]
-
^
a
b
Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D (February 1998). “Evidence for evolutionary conservation of sex-determining genes”.
Nature.
391
(6668): 691–5. Bibcode:1998Natur.391..691R. doi:10.1038/35618. PMID 9490411. S2CID 11414843.
-
^
a
b
Erdman SE, Chen HJ, Burtis KC (December 1996). “Functional and genetic characterization of the oligomerization and DNA binding properties of the Drosophila doublesex proteins”.
Genetics.
144
(4): 1639–52. PMC1207715. PMID 8978051.
-
^
Burtis KC, Coschigano KT, Baker BS, Wensink PC (September 1991). “The doublesex proteins of Drosophila melanogaster demark directly to a sex-specific yolk protein cistron enhancer”.
EMBO J.
10
(9): 2577–82. doi:10.1002/j.1460-2075.1991.tb07798.ten. PMC452955. PMID 1907913.
-
^
Shen MM, Hodgkin J (September 1988). “mab-three, a cistron required for sex-specific yolk poly peptide expression and a male-specific lineage in C. elegans”.
Prison cell.
54
(vii): 1019–31. doi:10.1016/0092-8674(88)90117-1. PMID 3046751. S2CID 1386352.
-
^
Yi W, Zarkower D (February 1999). “Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-three and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms”.
Evolution.
126
(5): 873–81. PMID 9927589.
-
^
a
b
Zhu Fifty, Wilken J, Phillips NB, Narendra U, Chan K, Stratton SM, Kent SB, Weiss MA (July 2000). “Sexual dimorphism in diverse metazoans is regulated by a novel course of intertwined zinc fingers”.
Genes Dev.
xiv
(14): 1750–64. PMC316782. PMID 10898790.
-
^
“Proteins matched: DM Dna-binding domain (IPR001275) filtered past species (Human being sapiens)”.
InterPro.
-
^
“Family: Dmrt1 (PF12374)”.
Pfam.
-
^
“Jpred results (MTECSGTSQPPPASVPTTAASEGRMVIQDIPAVTSRGHVENTPD)”.
www.compbio.dundee.ac.u.k.. Archived from the original on ten April 2019. Retrieved
ten April
2019.
-
^
“Species: DMRTA motif (IPR005173)”.
InterPro
. Retrieved
10 April
2019.
Source: https://en.wikipedia.org/wiki/DM_domain
